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Study Identifies 44 Genes Linked to Age-related Hearing Loss

A new study published in The American Journal of Human Genetics has identified 44 genes linked to age-related hearing loss, giving a much clearer understanding of how the condition develops and potential treatments, according to a press release on the King’s College London website.

In the study, researchers from King’s and University College London (UCL) analyzed the genetic data from over 250,000 participants of the UK Biobank aged 40-69 years to see which genes were associated with people who had reported having or not having hearing problems on a questionnaire. Forty-four genes were identified to be linked with hearing loss.

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By the age of 65, one-third of people are affected by some degree of hearing loss which can lead to social isolation and disability and has been identified as a risk factor for dementia.

Despite being a common impairment in the elderly, little is known about the causes of the hearing loss and the only treatment option available is hearing aids which are often not worn once prescribed. The findings of this study will allow researchers to determine how the condition develops as we age and may identify potential targets for new therapies.

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“We now know that very many genes are involved in the loss of hearing as we age. This study has identified a few genes that we already know cause deafness in children, but it has also revealed lots of additional novel genes which point to new biological pathways in hearing,” said Professor Frances Williams, co-lead author.

Co-lead author Dr Sally Dawson (UCL Ear Institute) said, “Before our study, only five genes had been identified as predictors of age-related hearing loss, so our findings herald a nine-fold increase in independent genetic markers. We hope that our findings will help drive forward research into much needed new therapies for the millions of people worldwide affected by hearing loss as they age.”

The next steps in this research are to understand how each identified gene influences the auditory pathway, providing opportunities to develop new treatments.

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Dr Ralph Holme, executive director of research at Action on Hearing Loss, said, “These findings are incredibly significant. We believe they will speed up the discovery of treatments to slow or even halt the progressive loss of hearing as we get older, something which happens to at least 70% of over-70-year-olds. This research was funded by us thanks to the generosity of our supporters and we know from people with hearing loss that being able to hear well again would completely transform their lives. The identification of these genes linked to age-related hearing loss throws open the door to many new lines of research into treatments.”

Original Paper: Wells HRR, Freidin MB, Abidin FNZ, et al. GWAS identifies 44 independent associated genomic loci for self-reported adult hearing difficulty in UK Biobank. American Journal of Human Genetics. 2019. DOI: https://doi.org/10.1016/j.ajhg.2019.09.008

Source: Kings College London, American Journal of Human Genetics

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